Bone Marrow Transplant | BMT Treatment for Blood Cancer in India

Bone Marrow Transplant-Types, Success Rate, Survival Rate and Best Hospitals in India

Bone Marrow Transplant (BMT)-Types, Success Rate, Survival rate and best hospitals in India

India has become a hub for a bone marrow transplant (BMT) over the last few years. The economical pricing of bone marrow transplant (BMT) procedure with a good survival rate and success rate offered by the Indian hospitals has led to this change. The medical tourism in India is increasing eventually with its rising fame in several treatment options.

Bone Marrow Transplant (BMT) in India:

Every hospital or center offering bone marrow transplant in India is facilitated with ultra-modern infrastructure along with widely experienced and even some internationally trained doctors and staff. Every type of bone marrow transplant (BMT) is available in India and the hospitals are fully equipped with all necessary equipment like a proper radiation and oncology unit for total body radiation, and chemotherapy drugs and equipments. Both autologous, as well as allogeneic bone marrow transplant (BMT), can be done efficiently as per the case requirement by utilizing bone marrow, cord blood stem cells, and peripheral stem cells. Several diseases like bone marrow disorders, leukemias, lymphomas, aplastic anemia sickle cell anemia, multiple myelomas, thalassemia, pediatric tumors etc can be treated by bone marrow transplant (BMT). Learn More about Bone Marrow Transplant.

What are the types of Bone Marrow Transplant (BMT)?

Every case has some certain specifications and limitations as well. Which can either be treated by one particular BMT option or at times different options can be applicable but your doctor can decide the best applicable option of BMT.

Following are the few options available in bone marrow transplant (BMT):

Autologous bone marrow transplant involves using the stem cells obtained from the patient’s own bone marrow. This is done in those patients who still possess some healthy stem cells. Before destroying the cancer cells by radiation or chemotherapy those healthy stem cells can be extracted from the patient and preserved under the required nominal conditions. Later those stem cells of the patient can be injected into the patient after complete irradiation of the cancerous cells. This method has fewer complication chances as rejection and graft failure chances are minimal.

Allogenic BMT is done preferably for some diseases. In this, a donor is required for obtaining stem cells. Allogeneic transplants require a matching donor with respect to the tissue or HLA matching. This type of bone marrow transplant (BMT) is applicable in cases where a patient’s own stem cells are completely damaged or destroyed to be used for autologous transplant. These transplants are prone to certain complications like graft-versus-host disease and other complications like graft failure, complete rejection etc. Finding a suitable donor can also be a tedious task. A donor can be a related or unrelated but with a complete match. Although getting a related match from a brother or sister poses lesser complications than an unrelated match. Since it further reduces the risk of rejection chances etc.

A donor undergoes a process of stem cell harvesting or stem cell collection. These days a new method of storing stem cells of newborn includes umbilical cord or placenta preservation in cord blood banks, such stem cells are not specialized so requires a minimal matching in comparison to adult stem cells.

There are different types of allogeneic transplants available based on the donor cells source.

They are listed below:

Related donor allogeneic transplant: Many relatives can be a source of stem cell donor but the ideal match must opt as it reduces the risk of complications to a minimum. Also, siblings are normally found to be a certain close match as a donor and identical twins can be an added advantage in such case.

Matched unrelated donor allogeneic transplant: These days there are certain international registrations done for donors. So in cases, where related matching donors are not available then these donor banks can be approached with global registrations to obtain a matching donor. It is a little tedious and time-consuming task but at times it can be the only hope for a perfect donor.

Half-matched related or family member donor allogeneic transplant: These days haploidentical bone marrow transplants (BMT) are routinely done in cases where more than 50 percent of a match is not available. In those cases, siblings, as well as parents, turn out to be a Hal-match or 50 percent match also known as the haploid match.

Cord blood transplants: This is the most recently available option for a bone marrow transplant (BMT). Especially in cases where even a minimum matching donor is not available. The cord stem cells obtained from the parental cord of the newborn are immature unlike in any adult stem cells, therefore, it does not even require a very close match with the recipient’s tissues.

What is the Success rate of Bone Marrow Transplant (BMT) in India?

Bone marrow transplant (BMT) has a predictable survival rate of nearly more than 60 percent. Every bone marrow transplant (BMT) case survival varies depending upon the type of transplant chosen like allogeneic or autologous. Even the complete replacement or removal of diseases marrow cells is not enough sometimes although it does efficiently work in most of the cases of transplant. The success and survival rates of any bone marrow transplant (BMT) depends greatly on patients condition and requirement. Bone marrow transplant (BMT) does cure some of the diseases and helps in extending life and improves the quality of life as well. But in some rare cases treating one disease leads to remission of another during or after the treatment. But those risks and complications and their chances can be discussed with a specialized doctor before undergoing a bone marrow transplant (BMT). Learn More About the Success Rate of BMT.

What is the Survival rate of patients have undergone Bone Marrow Transplant (BMT) in India?

People undergoing a bone marrow transplant (BMT) in India have a good survival rate. India has emerged as a global hub for several affordable but highly effective treatments. So any treatment in India including a bone marrow transplant (BMT) does have a good survival rate like in any other standard developed country but they charge too much unlike Indian economic prices for BMT. Several statistical data has been accumulated to date to support good survival rates offered by Indian BMT done for several diseases and age group patients. A relevant data states that nearly 30% to 40% of above 60 age group patients do survive more than 3 years after BMT done in India. The survival chances increase if younger is the patient age who are being treated and early is the diagnosis stage of the disease. Further, no reoccurrence until 2 years after BMT, even improves the chances of disease-free and longer survivals. Learn More About the Survival Rate of BMT Patients.

Which is the best hospital for Bone Marrow Transplant (BMT) in India?

Every hospital is good in its own way of offering facilities and treatment in India. But in order to find the best suitable as per your requirement reach us on the live chat and we can help you provide a list of best hospitals to choose. Several private hospitals offer a variety of prices for a bone marrow transplant. But several factors like the involvement of donor, sort of disease for which treatment is done, and the age of the patient plays an important role in setting up a probable price for the treatment. Learn More About the Hospitals have the highest Success Rate for BMT.

Related FAQs:

1) Q: Is Bone Marrow Transplant (BMT) really cure cancer?

A: Bone marrow transplant (BMT) can certainly help in treating several diseases like cancers, leukemia, myelomas etc. But a BMT as a definite cure can only happen in some cases which never relapse otherwise chances of relapse sometimes affect the complete curing ability.

2) Q: How long a cancer patient live after Bone Marrow Transplant (BMT)?

A: Patients survive long enough after bone marrow transplant (BMT). For eg: a person can survive for nearly five years after BMT if no complication arises and this survival even increases for the next 15 years and more if no relapse of the disease appears.

3) Q: Is it safe to donate bone marrow?

A: It is completely safe to donate the bone marrow and the procedure is done under the effect of anesthesia. The entire procedure is done under complete supervision in a hospital and requires a few days of recovery.

Where is low-cost bone marrow transplant surgery done in India? And what is the success rate?

The bone marrow transplant cost in India is highly cheap although the treatment is highly effective like the one provided in any developed country. A need of bone marrow transplant (BMT) might include several reasons starting from chronic diseases, infections, aplastic or sickle cell anemia, or big lymphomas, blood disorders like leukemia etc. all of these has one simple appearing but in a really complex solution of BMT. The bone marrow transplant cost in India might be variable but the average amount is still somewhere between 18 to 35 lakh which is comparatively cheaper and affordable. This economic average bone marrow transplant cost in India makes this place a destination for the treatment for world-wide patients across the globe.

Do the success rate of the bone marrow transplant varies as per its type or disease being treated for?

The bone marrow transplant cost in India as well as its success rate both are highly dependent upon what is the disease’s severity and type. Like autologous bone marrow transplant cost in India is lesser than the allogeneic bone marrow transplant cost in India. Because in autologous the healthy stem cell of the patient can be utilized for transplant unlike in the other case. Similarly in allogeneic dependency on donor and finding a right match can add up to the cost and even make success rate variable. Like there appears chances of rejection and GVHD in such cases.

Why is India a chosen place for bone marrow transplant?

The bone marrow transplant cost in India is so economic that India is becoming more and more popular for BMT these days. In the past few years, India has transformed into a low-cost BMT hub for several foreign patients. Every year several patients from countries like Oman, Iraq, Bangladesh, Srilanka, Kenya, Nepal, Myanmar, Nigeria etc are coming for medical tourism in India. The bone marrow transplant cost in India is far more reasonable than the prices offered by the UK, USA, Canada, and other developed countries. Besides, HLA identical sibling transplants Indian hospitals have massively started with new modern BMTs which are available worldwide with modern technology like cord blood transplant, unrelated donor matching transplants, and BMTs for leukemia in children and many immunodeficiency syndromes. Techniques involved during lymphoma treatments like total body radiations etc has also been incorporated in several well established Indian hospitals. So all these and economic bone marrow transplant cost in India is a center of attraction for all needy patients.

Related FAQs:

1) Q: Which malignant and non-malignant diseases can be treated with effective and economic bone marrow transplant cost in India?

A: A bone marrow transplant cost in India also varies depending upon the type it is treated for. Following are the few malignant and non-malignant diseases which can be treated by BMT:

BMT for malignant conditions includes Hodgkin’s and non-Hodgkin’s lymphoma; Acute myeloid leukemia, Chronic myeloid leukemia, Acute lymphoblastic leukemia, neuroblastoma, Multiple myelomas, Myelofibrosis etc.

BMT for Non-malignant conditions includes Sickle cell anemia, Aplastic anemia, Thalassemia, and Hemophagocytic syndrome etc.

2) Q: What happens if the blood cell count falls during any bone marrow disease?

A: A decrease in white blood cells impairs the body to fight against any infections, a lack of red blood cells provides insufficient oxygen supply to the body cells, and a decreased platelets count can cause excessive bleeding.

3) Q: What is an average bone marrow transplant cost in India?

A: The average bone marrow transplant cost in India varies between 18 to 35 lakh. It is a highly variable amount depending upon the type of hospital opted or the type of transplant you might have to undergo. A lower price than this is also offered by some of the Indian government tie up hospitals in India.

How much does bone marrow transplant procedure cost in India?

In the past few years the Indian Healthcare sector has experienced several ups and downs and going through all challenges and huge investments now India has transformed into a hub for all sort of medical treatments. The economic cost of high-quality medical treatments available in India is providing a cutting edge competition to several other countries in the healthcare sector. India has started an alliance with several countries to build up more trust and technology upon which people from the whole world can easily fall back.

Bone marrow transplant procedure requires a matching bone marrow. Although finding a matching donor is a big task and might consume a lot of money which can be saved otherwise in an autologous transplant. Upon an average, the bone marrow transplant procedure cost in India ranges between 18 lakh to 36 lakh. The pricing can even further go down to 8 lakh to 12 lakh in some government-run Indian hospitals offering bone marrow transplant procedure.

What makes the price differences vary of bone marrow transplant procedure in India?

The full and final cost of a bone marrow transplant procedure in India depends mainly on if you are getting an allogeneic or autologous transplant. In an allogeneic transplant bone marrow is obtained from a donor and this becomes one of the expensive types of transplants involving a hurdle of finding a matching donor as well. Another type of autologous transplant involves obtaining healthy stem cells of the patient which can be utilized for the transplant and this is one of the affordable options amongst bone marrow transplant procedures.

The cost of the bone marrow transplant procedure offered by every country varies significantly. Currently, India is considered one of the most reliable in terms of pricing offered for the bone marrow transplant procedure. The Indian procedure pricing is nearly a fraction of the amount being charged in UK, and USA.

What includes the pre-procedure cost and post-procedure cost?

The pre-procedure cost of the bone marrow transplant procedure includes a list of several tests which are done to analyze the patient’s in-depth condition. This helps to make the patient prepare for the procedure in every aspect and also it helps the doctor to carry out the procedure in a precise way.

After the bone marrow transplant procedure is over the cost of in-hospital stay along with medications and complications in rare cases makes up the post-procedure cost. Every hospital in India takes preventive measures to avoid all sorts of infections during and after the procedure which leads to complications and hence increases the cost of an entire procedure.

Rest for the foreign patients, the travel and accommodation costs also add up to the main procedure cost. But still, the entire overall bone marrow transplant cost will be lesser than being charged in other developed countries.

Related FAQs:

1) Q: Which is the most commonly opted source in the bone marrow transplant procedure?

A: Transplant of stem cell has opted readily since it develops early and produces blood cells. It can also be easily extracted from the blood instead of relying on bone marrow.

2) Q: What all adds up in the bone marrow transplant procedure cost?

A: Besides, the transplant certain health check-ups and examination, a source of new cells, blood tests, aftercare, chemotherapy, and radiation therapy etc all adds up in the cost of the procedure.

3) Q: Is it mandatory to receive Chemotherapy before bone marrow transplant procedure?

A: It is not mandatory but instead it depends upon the condition of the patient and what the doctor decides is best for the patient. Usually either ablative or high dose therapy or mini-transplant or low dose chemo is given to the patients.

BMT in India- Survival rate of patients after transplantation

In the past few years, there has been an immense increase in the number of hospitals offering BMT procedures. Although, awareness of a certain level is still required for this disease treatment. Bone Marrow Transplant in India might be available at comparative economic prices than other countries but it is still an expensive treatment. It requires detailed research to opt for the best hospital and doctors to treat such a lethal disease. In allogeneic transplants, the 5-year survival is nearly over 80 percent. Early diagnosis is helpful in early treatment with more survival chances and less fatal results than complicated late diagnosis cases. However, proper measures are taken by Indian hospitals as well as the qualified staff to minimize risks. Indian hospitals are equipped with specialized staff as well as modern equipment to deal with any sort of complicated BMT scenarios.

Why is survival important after Bone Marrow Transplant in India or in any country?

Bone Marrow Transplant in India is the best treatment procedure for several diseases. Hence, it becomes important that the procedure is done successfully no matter if it’s done in India or abroad. The success rate of the procedure is directly proportional to the survival of the patient. But the patients who undergo Bone Marrow Transplant are at risk of developing infections and sometimes even fatal complications which decreases the survival chances for a patient. The patients who undergo Bone Marrow Transplant in India has a good survival rate as all the standard procedures and norms are followed by professionals to minimize risks.

What can make the procedure of Bone Marrow Transplant in India terrifying for any foreigner?

There has been an immense increase in medical tourism in India. Besides, the deadliness of this disease the treatment in itself is also frightening. Foreign patients are new to India so their hassles increase for being dependent on unknown facts. However, these days things are more simplified for Bone Marrow Transplant in India and there are agencies, applications, and agents who counsel and guide the patients and their families about every aspect.

Further, getting a matching donor for Bone Marrow Transplant in India can become a hurdle and this can further be made simple by getting the matching donor along. Moreover, frequent visits to the country during and post Bone Marrow Transplant in India can appear a little tedious and tiring. For this, even the patient and the caretaker can stay in India until the hospital gives a clean chit for travel. The cost of BMT in India is comparatively so economic which comes out to be just a fraction of the amount offered by developed countries.

Related FAQs:

Q: What is a considerable average survival percentage after Bone Marrow Transplant in India?

A: It has been predicted from several kinds of research that the average survival rate of Bone Marrow Transplant is nearly 62 percent. Either allogenic or autologous the survival is dependent upon the success of the stem cell transplant and several risk factors like infection or rejection etc.

Q: What is the average cost of Bone Marrow Transplant in India?

A: Bone Marrow Transplant in India is very economical if compared with prices offered in other countries. Upon an average in any private hospital But procedure might cost between 16 to 35 lakhs. The pricing is based upon the hospital set up and the facilities they offer. This cost gets further reduced to 30-40 percent if its government hospital. There are few government hospitals offering BMT procedure between 7 to 8 lakh in Rajasthan. A related donor match among the family like parent or sibling also reduces the cost.

Q: Can Bone Marrow Transplant leave any forever physical impact on a person’s mind or body?

A: There are several types of research ongoing on this issue. It has been observed in rare cases, that BMT might alter a person’s behavior because of an impact over the brain ecology. Further, even an odd effect of Bone Marrow Transplant involves blood type alteration for life long post-procedure.

BMT in India- What difficulties patients have to face during treatment?

BMT in India is the procedure done in high numbers. This involves Indian as well as many foreign patients. In this procedure, replacement of the damaged bone marrow is done with such bone marrow stem cells which are healthy and efficient. A person must undergo a BMT in India if he or she is unable to make sufficient blood count and is looking for economic treatment or in order to combat any underlying disease of aplastic anemia, leukemia etc. The procedure of BMT in India is highly successful and is performed by skilled professionals in every hospital.

Why BMT is becoming an urgent need for the patient?

The survival of the person depends upon his body’s capability of fighting against infections and diseases. Whereas a damaged or malfunctioned bone marrow makes a person all these abilities to combat against diseases. So it becomes mandatory for the person to seek treatment and get bone marrow transplant in such cases.

What you must look for in a matching donor during BMT in India?

Finding a donor during BMT in India can be a hurdle because donor registration in NOTTO or National Organ and Tissue Transplant Organization is not followed here. Moreover, India has very few donor registers and amongst all the reliable and oldest one is MDRI or Marrow Donor Registry India.

There are few tips to follow while finding a matching donor during BMT in India:

• The age group of the donor must be between 18 to 50 with good health. The younger the donor the better it will be for the patient.

• A donor must be free from any diseases like of cancer, cardiac, liver, kidney, diabetes, and even obesity etc.

• A donor must also be free from any kind of high-risk viral diseases like AIDS etc.

India still requires a lot of awareness for the need of donor registration so as to motivate people to register once they turn eligible. Once this is done more and more lives with ease could be saved.

What can make the BMT in India more difficult for the patients?

BMT in India appears partially difficult for some patients and their families. Especially the foreign patients and such patients who are looking for the best economic treatment options. Insurance covers also do not provide a full cover on diseases which require BMT. India is already offering economic services for its patients in comparison to global treatment prices.

It involves a huge investment though but still, there are endless hospitals in India who are competing to strive and provide the best available treatment globally, within the country itself. BMT in India also involves those risks of transplant like in any other country. These complications can be mild to severe and sometimes life-threatening as well.

It includes:

• Infections, organ injury, transplant rejections.

• Allogenic transplants also include graft-versus-host disease in some cases which affects the skin, liver, eyes, lungs, and digestive system.

• New cancer or even death in rare cases etc.

Related FAQs:

Q: Is it important for the patient and the donor to have the same blood group?

A: No blood group matching is not mandatory. Instead, HLA typing in DNA must match 6 to 10 major markers for an ideal match.

Q: Procedure of BMT in India or bone marrow donation requires any removal of the bone part?

A: No, BMT in India does not require any bone piece removal at any stage of the procedure. Only stem cells are obtained either from a blood sample or fluid present inside the bone.

Q: Any surgery is involved in bone marrow donation process?

A: In most of the cases of BMT in India, stem cells are obtained via peripheral blood stem cell donation without any surgery. Although, a very less fraction of nearly 5 to 9 percent of cases might involve a surgical procedure to obtain stem cells.

BMT in India- How can I get low-cost treatment

Looking for affordable BMT in India is really easy. India itself offers a wide range of quality and cost-effective treatment and procedure options. Further, reaching out the best economic hospital in India can be tricky but not difficult. There are several hospitals offering packages at economic prices for Bone Marrow Transplant in India. You may find several medical tourism companies to help you reach out the best hospital as per your need.

Cost-efficacy of Bone Marrow Transplant in India?

There are many cost-effective treatment options available for Bone Marrow Transplant in India. It involves the complete replacement of damaged hematopoietic stem cell and this procedure is also known as HSCT. The donor’s hematopoietic stem cells regenerate the patient’s hematopoietic system over the time and makeup WBC, RBC, and platelets and the blood count reach the desired values. The most cost-effective But in India can be autologous stem cell transplant in which patient’s own healthy stem cells are re-infused during treatment. But every individual cannot be eligible for the same. Since this requires healthy stem cells and not the damaged ones to re-boost the system again. This procedure minimizes the time, cost and effort in finding a matching donor. Other than this peripheral blood and cord blood transplant are the available options.

Why is the cost of Bone Marrow Transplant in India more in few hospitals and low in others?

The high-cost variation of Bone Marrow Transplant in India among several hospitals is often linked with several factors. Some of these include poor insurance cover availability; different staging or diagnosis equipment and procedure costs because of the difference in facilities provided by each hospital etc. The costing of Bone Marrow Transplant in India is comparatively cheaper than offered by many other developed countries. Although, during BMT in India variation of cost can be felt even in HLAs compatibility testing of related or unrelated donors. So small-small variations in cost add up and make a huge difference. The best way is to opt for the hospital as per budget and facilities required this minimizes the hassle of dealing with finances at each step during the Bone Marrow Transplant procedure.

The cost of BMT in India, offered by each hospital is also impacted by the team of specialized professionals and high-tech equipment and other amenities the hospital possess.

How can the cost of Bone Marrow Transplant in India be further minimized?

By taking proper measures and precautions to avoid complications during and after Bone Marrow Transplant in India helps in minimizing the extra cost which adds up to the expenses. The occasional cases of stem cell rejection causing a complete failure of the procedure. It leads to an extension of hospitalization under aseptic conditions and further increases the cost of Bone Marrow Transplant as well.

Related FAQs:

1) Q: Is it really dangerous to undergo Bone Marrow Transplant procedure?

A: BMT procedure is completely safe although like any other procedure it does have some risks of developing complications. Stem cell engrafting failure in allogeneic transplant is the main risk though, it does not happen in all cases.

2) Q: Which Bone Marrow Transplant is best for my case? How do I confirm it?

A: Your treating physician is the best person to guide you on this after the complete analysis of your condition. You may also choose to discuss and get the second opinion about your diagnosis and treatment from another expert as well. Usually, a coordinator in every hospital is given the duty of clearing all your doubts.

3) Q: After how long I can get back to work after Bone Marrow Transplant in India?

A: Because of decreased immunity and increased risk of infections it is suggested always to avoid work and crowded places. Usually, a resting period of 3-6 months after an autologous transplant and 6-12 months after allogeneic transplant is recommended for complete recovery. During this time the body regains lost strength and immunity. Further, the resting period might vary depending upon complications if any or your health condition. You must always seek your treating physician’s advice before returning to work.

Bone Marrow Transplantation for Lymphoma

Lymphoma is a kind of cancer which develops because of the lymphocytes mainly. White blood cells which protect the body against several infections are a type of lymphocytes which get impaired in lymphoma. The lymphocyte gets accumulated in lymph nodes or spread to several body parts causing a traumatic condition of lymphoma. Its main origin is from the immune system itself since it involves lymphocytes and these multiply in uncontrolled numbers spreading to spleen bone marrow, thymus, lymph nodes etc.

Lymphoma is mainly divided into the following types:

• Hodgkin Lymphoma

• Non-Hodgkin lymphoma

Depending upon a specific type a particular bone marrow transplantation can be suggested by your physician for treatment. You must consider sharing all your previous medical history details with your physician before starting with any specific treatment in order to prevent any last moment complications.

Which different types of bone marrow transplantation can help in treating lymphomas?

Bone marrow transplantation helps in treating even the advanced staged lymphomas. But it requires a completed in detailed diagnostic analysis of the condition. Which can be done by an expert who is specialized in the diagnosis and treating cancers or lymphomas.

The three different transplant types are listed below based on its donor:

• Syngeneic Transplant: In this, the stem cells are donated by an identical twin of the patient.

• Autologous Transplant: In this, Stem cells are obtained from the patient itself. Healthy stem cells if present is used as a source of bone marrow transplantation in some cases.

• Allogeneic Transplant: In this, a related or unrelated donor with a close match or complete match of stem cells is the source for transplant.

Depending upon case your physician can suggest the best suitable bone marrow transplant for you after a complete analysis of the condition.

What role does bone marrow transplantation play in lymphomas?

Bone marrow transplantation replaces the unhealthy or damaged blood-forming cells with the healthy ones. The process is termed as bone marrow transplant or stem cell transplant. It involves either autologous transplant in which cells are obtained from the patient itself or allogeneic transplant in which source of healthy stem cells is a related or unrelated donor.

In the case of Hodgkin’s Lymphoma autologous transplant is the most common type. It involves high dose chemotherapy sessions followed by a transplant. Although, chemo is required in mostly both kinds of transplants initially to kill the cancerous cells or lymphomas in the body. After that new cells are infused which travels inside the body to reach bones and reboot the process of blood cell production again.

Everything is done in a hospital under proper observation and measures are taken to prevent and minimize post-procedure complications.

Related FAQs:

1) Q: What are the different signs and symptoms of lymphomas?

A: Its signs include enlarged or swollen lymph nodes, chest pain, extreme fatigue, shortness of breath or even cough, abdominal swelling, occasional chills, and weight loss etc.

2) Q: Is there any difference between stem-cell transplant and bone marrow transplantation?

A: The main difference lies in the fact from where the donor cells are obtained. Like stem-cell transplant or peripheral blood stem-cell transplant involves extraction of cells from the peripheral or circulating blood of the body whereas in bone marrow transplantation the source is bone marrow itself. The procedure of stem-cell transplant is comparatively easy and involves quicker regeneration of new cells in the body.

3) Q: Which type of bone marrow transplantation are common for Hodgkin Lymphomas (HL)?

A: Autologous, as well as allogeneic bone marrow transplantation, are the most preferred ones for Hodgkin Lymphomas. But your physician can only suggest the best suitable type of bone marrow transplantation as per your case.

Bone Marrow Transplantation for Sickle Cell

Bone marrow Transplantation is the best way to cure sickle cell disease or SCD. It is a little complex procedure than it appears to. Since it involves many things and the first one is finding the right hospital and a doctor. You must look for the best doctor who performs bone marrow Transplantation to discuss your or your relative’s case in depth. There are several concerns from finding a donor to combating financial expenses as well as post-transplant complications etc.

Sickle cell disease is caused by a hereditary defect with which you are born. It leads to abnormal sickle-shaped hemoglobin and hence makes it incapable to carry and deliver oxygen throughout the body, which is its main job. It even causes pain episodes due to blockage of blood flow in tiny veins. It can further use damage to brain, kidneys, heart, and other organs fo the body. So in order to prevent all organ damage bone marrow Transplantation becomes the only source or treatment.

Sickle cell disease is mainly a genetic disease which is passed from parents to their offsprings. These defective genes guide the blood-forming stem cells to produce defective sickle-shaped hemoglobin and hence there becomes no control of any drug over it and to stop it further a person must undergo bone marrow Transplantation.

How bone marrow Transplantation can help to treat sickle cell disease?

During bone marrow Transplantation, defective hematopoietic stem cells of the body are replaced with healthy ones. It is done by infusing healthy donor stem cells into the body. This helps in stopping more production of sickle-shaped cells causing SCD.

What are the complications during bone marrow Transplantation?

Like in any procedure this one also has its own attached risks and complications. But it is not mandatory you will experience them always. Also sometimes the increased episodes of pain in sickle cell disease make it essential to undergo bone marrow Transplantation even if there is certain risk involved.

Some of the complications include:

• Graft-versus-host disease (GVHD) in case of rejections against bone marrow Transplantation. This happens very rarely and drugs can help in preventing this. But if somehow medicines do not work than it might lead to multiple organ damage.

• Some damage of liver vessels can be caused during treatment.

• Infections are very common to appear because of low immunity and precautions and medicine both in combination can help to prevent it.

• The drugs used during bone marrow Transplantation sometimes negatively affect the fertility and infertility can be caused by them.

Normally nine out of 10 cases of bone marrow Transplantation turn out to be successful. However, in rare cases of transplant failures and rejections, another transplant might be required depending upon the condition of the patient.

Related FAQs:

1) Q: Is it okay to get pregnant if a woman has sickle cell disease?

A: Yes, women can get pregnant since there are no specific severe problems caused by SCD during pregnancy. However, precautions will be required. SCD poses more risks of urinary tract infections during pregnancy and chances of developing severe anemic condition also increases due to less iron consumption.

2) Q: Is nickel cell disease a fatal disease?

A: Yes, it can turn out to be fatal if not treated on time. Extreme pain episodes, stroke, infections, and acute chest syndrome are very common to appear. But at times vast-occlusive crisis can even cause death in SCD.

3) Q: Is there any way to test the fetus for sickle cell anemia during pregnancy?

A: Yes, there are two tests for gene inhabitation which can be done. It involves certain techniques like chorionic villus sampling and amniocentesis, in order to know about the presence of SCD.

BMT in India- Hospitals have the highest Success Rate

The increasing medical advancements in recent years in India have taken the entire world by storm. Modern and advanced India is carving a niche for its own identity by providing effective and affordable medical treatments for such diseases which are a global issue these days. The cost-effectiveness of the medical procedures like BMT in India given by several hospitals is leading its way for medical tourism as well. A cut-throat competition given by India to several developed countries by charging just a fraction of the cost being charged by other counties is a huge transformation in the medical field.

Bone Marrow Transplant in India is offered by several hospitals which possess a team of trained medical professionals who have their specialization in hematology and oncology. To help and assist them there is another team of trained professionals including doctors and nurses etc. The high success rate of the procedure achieved by the hospitals is both due to good professionals as well as of the equipped diagnostic and treatment materials which are kept up to date as per the modern technology.

When you should go for a Bone Marrow Transplant in India?

Bone Marrow Transplant in India is far more economical and hassle-free. So go for it in case you are suffering from:

• Damaged immune system which needs a regeneration which can be done by BMT.

• A bone marrow degeneration caused by any genetic disease like Hurler’s syndrome or adrenoleukodystrophy etc.

• The bone marrow malfunctioning caused by high dose chemotherapy or radiation to treat any brain tumor or any other cancers etc.

• Leukemia, Aplastic Anaemia, Sickle Cell Anemia, and other blood disorders which requires Bone Marrow Transplant to cure the condition.

Bone Marrow Transplant in India? What does it involve during the procedure?

There are several options available for BMT in India.

Some of them are listed below:

• Autologous transplant: In this stem cells are obtained from the patient’s body itself.

• Allogenic transplant: In this procedure, matching stem cells are obtained from their parents, siblings or any other unrelated donor.

• Syngeneic transplant: In this procedure source of stem cells is the identical twin of the patient.

• Umbilical cord transplant: This procedure involves the use of stem cells obtained from the umbilical cord of the newborn. These days several cord blood banks preserve the cords against some fees for a specific period and hence this cord can be used as a source for stem cells if required in future. This also reduces an effort and time to find a matching donor in the critical circumstances.

Related FAQs:

Q: What is the survival percentage and success rate after Bone Marrow Transplant in India?

A: India has transformed a lot in the medical field. Bone Marrow Transplant in India today has reached a survival point of nearly 62 percent and the success rate of Bone Marrow Transplant is also increasing with the application of high tech modern technology in India. Every hospital dealing with Bone Marrow Transplant has a good success rate.

Q: What is done during the Bone Marrow Transplant procedure in India?

A: The procedure of Bone Marrow Transplant in India, involves a basic process of removal of damaged stem cells and is further replaced with healthy stem cells by transplantation. Healthy stem cells can either be obtained from a donor or preserved umbilical cord from the blood cord bank.

Q: What is the average procedure cost of Bone Marrow Transplant in India?

A: Bone Marrow Transplant cost in India varies specifically as per the patient’s need and also because of a variety of facilities offered by hospitals. Upon an average, the BMT in India cost varies between 10 lakhs to 35 lakhs, which is a comparatively affordable price offered in comparison to other countries. This range Bone Marrow Transplant in India further goes down in the government hospitals of Rajasthan. In the last few years, Bone Marrow Transplant in India has emerged as the most affordable option.

Are Bone Marrow Transplants Successful?

A bone marrow transplant(BMT) or also known as stem cell transplant recently is the only treatment for several types of cancers. Like Multiple Myeloma, Leukemia, some blood diseases, and for several kinds of Lymphomas etc. The bone marrow transplant cost also varies significantly for different cases as per the requirement of the disease treatment. In previous times, it was more often to term it as a bone marrow transplant because of extraction of stem cells from the bone marrow. However, these days stem cells can directly be extracted from the blood and due to that it is more commonly termed as stem cell transplant now. The advancement of the medical field is not just confined to stem cell extraction but it has also impacted its cost with several options available these days. Previously BMT success rate was too low but now with increasing requirement of the procedure efforts has been made along with several kinds of research to create better economic options with increasing bone marrow transplant success rate.

The BMT success rate varies along with its cost depending upon the requirement of the individual. If a transplant is done from your own body than it is an autologous transplant and if it involves a donor than it is an allogeneic transplant. Involvement of matching donor increases bone marrow transplant success rate.

Why is there a need for a bone marrow transplant?

With increasing numbers of blood and other disorders at times, a BMT is the most successful option in terms of curing disease.

Some of the cases needing high bone marrow transplant success rate include:

• For complete replacement of damaged or diseased bone marrow cells

• For providing new stem cells to help killing cancer cells.

• For a safe and effective high dose chemotherapy or radiation treatment in few cancers followed by replacement of damaged bone marrow.

How a bone marrow transplant success rate can be evaluated?

A successful bone marrow transplant has a direct dependency on how closely the donor and recipient bone marrow matches. At times it becomes difficult to find a perfectly matching genetically same bone marrow from the unrelated donors which greatly affects BMT success rate.

Another hurdle is not the cost but instead an engraftment phase of the procedure which takes normally 10 to 28 days after the transplant. If this fails then the whole BMT success rate declines. So this phase is monitored closely and its success signs start with an increase in white blood cell count indicating that the blood cells are rising to normal being newly formed.

The complete success of the BMT varies from case to case considering several factors and complications. Although most of the transplants are successful with rare cases of failure which can further be minimized with preventions and proper monitoring.

Related FAQs:

1) Q: What are the new options available in bone marrow transplants?

A: Bone marrow transplant success rate, as well as treatment options, vary tremendously and it has raised the survival rates graph from zero to over 85%. Several options include cord blood transplants, haploidentical transplants, and reduced-intensity transplants etc.

2) Q: What happens to the bone marrow transplant success rate if healthcare team is unable to find a perfect match of bone marrow donor?

A: In that case, the following options are available for the increasing bone marrow transplant success rate:

• Haplotype mismatched or parent–Child transplant: In this, a 50% matching donor including a parent, child, brother or a sister can be used instead of a complete 100% match.

• Umbilical cord transplant: This is another option if a donor match could not be found. All around the world cancer centers use cord blood for stem cell or bone marrow transplant.

Bone Marrow test cost in India

Bone Marrow is the soft gelatinous tissue found inside the bones of the human body. It is mainly responsible for the production and maturation of blood-forming stem cells in the body. These mature stem cells are then released into the peripheral bloodstream where they differentiate into the three types of blood cells, namely, the red blood cells, the white blood cells, and the platelets.

What is a Bone Marrow Test?

The bone marrow test or biopsy is a specialized diagnostic procedure in which a certain portion of the marrow tissue is obtained and is then tested under the microscope. It is a fairly regular procedure which is done to detect various blood-related disorders. These could be blood cancers (leukemia and lymphoma), anemia, Sickle Cell Anemia, Thalassemia, Neutropenia etc.

It basically gives a better idea of what is going on inside the body when the doctors are unable to find the answers with other specialized tests.

How often is this procedure done?

Due to its positive results, the test is done to know the exact cause of certain blood disorders. Also, it harbors Stem Cells. Stem cells are pluripotent cells which means that they can basically turn into any type of cells under the influence of certain growth factors.

The procedure is done by all the doctors, nurses and other health care professionals in the laboratories. The test consists of two procedures i.e. the bone marrow aspiration and the bone marrow biopsy.

In India, all the leading private hospitals, government hospitals and most of the well-equipped laboratories offer this test. It is a fairly safe and regular procedure. Doctors do it all the time.

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How much does the test cost?

India is becoming one of the leading medical hubs in the world. Globally, it is earning respect in terms of medical services and the qualified medical staff. The doctors here are hardworking and well trained to perform all kinds of procedures.

In India, the cost of the bone marrow test depends upon various factors. The bone marrow test cost in India varies directly upon the type of facility (public or private), the city or patient’s location, and also the availability of the test.

The bone marrow test cost ranges from Rs. 500-5000 in India. This is obviously the average cost of the test. The bone marrow test cost can increase in case of any unforeseen complication that might occur.

As per the regular privately purchased health insurance, usually, the bone marrow test cost is included in the coverage. The cost of the test is usually reimbursed to the patient. In India, the bone marrow test cost is sometimes subsidized by the government for those patients who cannot pay the amount. There are many hospitals which come under this subsidized low-cost bone marrow test in the country.

About BloodCancerCure:

BloodCancerCure is the world’s first such organization working 24*7 on helping blood cancer patients. BloodCancerCure works for patients across the world by providing the lowest cost for bone marrow transplants, chemotherapy, and Bone marrow test. You can contact at +91-8448533753 to talk to our experts at BloodCancerCure for BMT treatment in India.

Is Bone Marrow Cancer curable? What are the treatments?

What is a Cancer?

Cancer, as we know, is the abnormal proliferation of certain cells of the body which goes out of control. Cancer can develop practically in all parts of the body.

There are two types of cancerous lesions that are found in the human body.

These are:

Benign Cancer: It is the less dangerous one (unless it is impinging on surrounding tissues) as it doesn’t spread to other organs.

Malignant Cancer: It is the problematic one as it can rapidly spread to other tissues and can even cause a variety of other problems.

What is Bone Marrow Cancer?

Bone Marrow is the soft gelatinous substance present inside the bones. It is kind of like the manufacturing unit for production of blood cells in the body. It consists of many types of precursor blood cells, stem cells, mature cells etc.

It is actually the abnormal multiplication of any of these cells inside the bone marrow. Since the bone marrow has a direct connection with the blood supply, it can easily spread to other parts of the body.

What are the symptoms of Bone Marrow Cancer?

Any cancer for that matter does not have serious direct consequences. They usually create a problem with normal functioning of the body. in bone marrow cancer, the production of normal blood cells is hampered, or there is drastic increase in one type of the cell. As a result, the number and functioning of other cells are affected.

The following are the symptoms associated with it:

Anemia
Weight loss
Bleeding disorders
Fatigue and tiredness
Increase the frequency of infections
Immune-compromised state
Body pain
Bone weakness and frequent fractures
Kidney damage

What are the types of Bone Marrow Cancer?

The type of bone marrow cancer depends upon the type of the cell involved.

The types of cells are:

The red blood cells
The Platelets
The White blood cells which include lymphocytes, plasma cells, leukocytes etc.

Let us find out about some of the common types of bone marrow cancer.

Multiple Myeloma:
It is characterized by the excessive proliferation of plasma cells in the bone marrow. Plasma cells play a key role in forming antibodies against the various types of infections.

Leukemia:
This is characterized by a rapid increase in the number of white blood cells. This increase in the number of cells can be rapid (acute- ALL, AML) or slow-growing (chronic- CML, CLL).

Lymphoma:
This is the cancer of the lymphatic system. These can occur in many parts of the body.

This is of further two types: Hodgkin’s and Non-Hodgkin’s Lymphoma.

How is Bone Marrow Cancer diagnosed?

A doctor can make a number of diagnoses based on the symptoms that patients present with. The doctor can order various tests such as complete blood counts (CBCs), and certain imaging tests. Blood tests help to evaluate the blood counts, kidney function, and electrolyte levels. The imaging tests such as the MRI scan, CT scan or PET scan helps the doctor to evaluate the spread of the bone marrow cancer.

Another important technique to determine the type, severity and the spread of bone marrow cancer is the bone marrow biopsy. It is a confirmatory test for all the types of bone marrow cancers and blood disorders. The aspirated bone marrow is looked by a specialist under a microscope to get a clear picture of what is going on and plan treatment accordingly.

How is Bone Marrow Cancer treated?

The treatment of this cancer is very customizable according to each specific cancer. After the doctor determines the type, spread and the grade of cancer, an oncologist can design a specific course of treatment for a patient.

The two most common mode of treatment is Radiation therapy and Chemotherapy.

These can be used alone or along with each other as a part of adjuvant therapy. Both of these treatments are aimed at killing the cancer cells or stopping them from multiplying. The drugs may have targeted action on some kind of cancer cells.

For example, Imatinib (Gleevec) is a drug which is effective mainly for CML (a type of bone marrow cancer)

Patients generally start to lack the number of healthy blood cells required to perform normal day to body functions either due to bone marrow cancer treatment or due to the disease itself.

In such patients, physicians recommend a bone marrow transplant. it is a highly specialized procedure in which the healthy bone marrow is transferred into the deceased individual to take over the normal functions.

It is of three types: Allogenic, Autologous, and Syngeneic.